Estrobolome Gut Bacteria Help Balance Hormones

Estrobolome Gut Bacteria Help Balance Hormones

Probiotics are well known for their ability to strengthen the immune system and promote digestive health [1, 2], but if you have been wondering how to balance hormones, a special type of bacteria in the gut called estrobolome have been shown to influence estrogen activity [3]. More specifically, estrobolome gut bacteria regulate the circulation and excretion of estrogens through the intestines and liver by producing an enzyme called beta-glucuronidase.

How does beta-glucuronidase work?

This enzyme alters the structure of estrogens causing inactive forms to become active. Subsequently, active, freely circulating estrogens can bind to other cells in the body in order to influence estrogen-dependent processes. For instance, estrogen activity in the breast promotes cell growth and development [3].

Healthy estrobolome promote the production of beta-glucuronidase levels that maintain an optimal estrogen balance, but certain factors such as diet and some forms of medication (e.g. antibiotics) can cause an estrobolome imbalance as well as reduced beta-glucuronidase activity [3, 4]. A diet that is high in protein or fat can increase beta-glucuronidase activity, while consuming too much fiber can decrease its activity [5, 6].

Furthermore, taking antibiotics can decrease the number of estrobolome gut bacteria [3]. These types of changes may lead to excessive amounts of circulating estrogens or a deficiency, both of which can lead to estrogen-related health problems such as impaired cognitive function, metabolic syndrome, endometriosis, cardiovascular disease, polycystic ovary syndrome, cancer, and obesity [7].

Estrobolome supports health in both women and men

Although an estrobolome imbalance may lead to altered estrogen levels and the onset of conditions such as polycystic ovary syndrome, endometriosis, and endometrial hyperplasia (the abnormal thickening of the uterine lining) in women, a form of estrogen called estradiol also plays an important role in male sexual health [3, 7]. Accordingly, research shows that estrogen imbalances are associated with breast cancer as well as prostate cancer [8, 9].

Clinical studies indicate that women who have breast cancer have significantly altered gut estrobolome composition (structural changes) and a lower diversity of gut bacteria [10]. Similarly, decreased estradiol levels increase the risk of prostate cancer in some men, and the disruption of normal estrobolome activity due to antibiotics or an unhealthy diet, for example, can negatively affect estradiol production [9]. Therefore, estrobolome supplementation is a natural way to balance hormones and is becoming an increasingly popular option for the maintenance of optimal hormone levels.

How to tell if you may be suffering from a hormonal imbalance

Do you frequently suffer from any of the following health issues?

  • Bloating, abdominal cramps, gas
  • Diarrhea and/or constipation
  • Chronic fatigue
  • Increased stress Impaired mental performance
  • Problems digesting beans or fiber
  • Food sensitivity to dairy or gluten
  • Vaginal or anal itching
  • Frequent stomach infections
  • Sinus congestion
  • Acid reflux or heartburn

If you experience several of these health problems on a regular basis, finding natural ways to balance hormones may help improve your discomfort. More specifically, an estrobolome supplement is a natural approach that can help prevent or target hormonal imbalances, estrogen-related conditions, and additional health problems.

Also Check How to Choose a Good Probiotic?


  1. Kawamoto S, Maru-a M, et al. Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis. Immunity. 2014;41(1):152-65.
  2. Ritchie ML, Romanuk TN. A meta-analysis of probiotic efficacy for gastrointestinal diseases. PLoS One. 2012;7(4):e34938.
  3. Kwa M, Plottel CS, Blaser MJ, Adams S. The Intestinal Microbiome and Estrogen Receptor-Positive Female Breast Cancer. J Natl Cancer Inst. 2016;108(8).
  4. Plottel CS, Blaser MJ. Microbiome and malignancy. Cell Host Microbe. 2011;10(4):324-335.
  5. Reddy BS, Hanson D, Mangat S, et al. Effect of high-fat, high-beef diet and of mode of cooking of beef in the diet on fecal bacterial enzymes and fecal bile acids and neutral sterols. J Nutr. 1980;110(9):1880-1887.
  6. Reddy BS, Engle A, Simi B, Goldman M. Effect of dietary fiber on colonic bacterial enzymes and bile acids in relation to colon cancer. Gastroenterology. 1992;102(5):1475-1482.
  7. Baker JM, Al-Nakkash L, Herbst-Kralovetz MM. Estrogen-gut microbiome axis: Physiological and clinical implications. Maturitas. 2017;103:45-53.
  8. Pike MC, Spicer DV, Dahmoush L, Press MF. Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiol Rev. 1993;15(1):17-35.
  9. Nelles JL, Hu WY, Prins GS. Estrogen action and prostate cancer. Expert Rev Endocrinol Metab. 2011;6(3):437-451.
  10. Goedert JJ, Jones G, Hua X, et al. Investigation of the association between the fecal microbiota and breast cancer in postmenopausal women: a population-based case-control pilot study. J. Natl Cancer Inst. 2015; 107(8): pii: djv147.
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